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AstraZeneca Pharmaceuticals LP
,
Macclesfield, Cheshire
Process Engineers - Chemical Development
Overview
Job Description
Position: Process Engineers - Chemical Development Location: Macclesfield, UK Salary: Competitive & Excellent Benefits Package AstraZeneca is a global, innovation-driven biopharmaceutical company where we not only focus on the discovery, development and delivery of life-saving medicines to our patients but believe in sustainability and are determined to minimise the impact of our work on the environment. We are proud to be a great place to work and have a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity. Chemical Development: In Chemical Development, we believe that nothing is impossible, and we are compelled to push the boundaries of science to deliver medicines to our patients. We combine people's technical knowledge and understanding, with their talent and drive to design, develop and optimise synthetic routes that deliver the active pharmaceutical ingredients of our medicines, in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop. In our process engineering teams, we currently have open positions for two Process Engineers. The responsibilities and requirements of the position are outlined below. As a Process Engineer you will work closely with fellow chemical engineers, chemists, analysts, crystallisation scientists and statisticians to develop, optimise and scale-up chemical processes to deliver robust and sustainable drug substance manufacture. Key Responsibilities: + Provide engineering expertise to the development and optimisation of chemical processes, to achieve robust and sustainable processes for delivery of drug substances. This includes laboratory experimentation, modelling and simulation and assessment of the results obtained. + Carry out scale-up and manufacturability assessments of processes to ensure right first-time scale-up, technical transfer and future viability. + Work closely with our Contract Manufacturing Organisations (CMOs) across the globe, providing engineering input into process development and the accommodation of processes into manufacturing facilities. + Carry out process assessments including environmental, materials of construction and process safety assessments to accommodate chemical processes in our internal manufacturing facility to deliver drug substance for clinical trials. + Drive learning from manufacturing and deliver process improvements which can be implemented in future manufacture. + Support problem solving when issues arise. + Work closely with our colleagues in Drug Product Development to understand the requirements for the physical properties of drug substances and develop processes providing these properties. + Champion and drive sustainability of chemical processes with respect to environmental sustainability, efficiency and cost. + Work closely with our colleagues in Supply Chain, providing engineering input in technical discussions with our suppliers. + Participate in the overall drug substance control strategy, ensuring processes are fully understood and will robustly deliver the same drug substance quality. + Develop external contacts (industrial and academic) to bring learning and alternative process engineering science into AstraZeneca. + Apply technical knowledge to improvement projects and the evaluation of new technology / processes, ensuring Best Available Technology (BAT) is assessed and implemented. + Mentor and supervise junior colleagues and university students. Essential requirements: + A degree and / or PhD in Chemical Engineering. + A well-developed understanding of unit operations such as mixing, distillation, liquid-liquid extraction, isolation and drying and their dependency on scale and equipment. + Good collaborative skills to enable effective working with different skillsets. + Have a good understanding of the requirements, principles and application of Safety, Health and Environment (SHE) regulations and Good Manufacturing Practice (GMP). + Strong communication and influencing skills. Desirable Requirements: + Experience working in the Pharmaceutical or Fine Chemicals Industry. + Experience of chemical process development scale up and / or technical transfer. + Experience of working across skillsets (e.g. with chemists, analysts and physical properties experts). + Ability to use modelling software (e.g. Aspen, DynoChem, Computational Fluid Dynamics) to support process understanding. + Experience working with CMO's. + Experience in leading technical projects or act as a lead process engineer on the projects. Please note that applications must include your current CV and a cover letter and be submitted before midnight on 18th December 2019