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AstraZeneca Pharmaceuticals LP
,
Macclesfield, Cheshire
Associate Principle Scientist - Process Engineer
Overview
Job Description
Position: Associate Principle Scientist - Process Engineer Location: Macclesfield, UK Salary: Competitive & Excellent Benefits Package AstraZeneca is a global, innovation-driven biopharmaceutical company where we not only focus on the discovery, development and delivery of life-saving medicines to our patients but believe in sustainability and are determined to minimise the impact of our work on the environment. We are proud to be a great place to work and have a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity. Chemical Development: In Chemical Development we believe that nothing is impossible, and we are determined to push the boundaries of science to deliver medicines to our patients. We combine people's technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes that deliver the active pharmaceutical ingredients of our medicines in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop. We have an open position for an Associate Principle Scientist - Process Engineer in our process engineering team. The responsibilities and requirements of the position are outlined below. As an Associate Principle Scientist, you will be a scientific leader in growing process engineering (currently 16 process engineers) and the overall scientific community across Chemical Development. Together with your colleagues in other skill areas you will plan and drive improvement projects that will vary from technical activities, use of new technologies or modifying our ways of working within AstraZeneca or externally with our Contract Manufacturing Organisations (CMOs). On development projects you will work closely with fellow chemical engineers, chemists, analysts, crystallisation scientists and statisticians to develop, optimise and scale-up complex chemical processes to deliver robust and sustainable drug substance manufacture. Key Responsibilities: + Lead or contribute to complex projects focusing on process development and the manufacture of drug substances. + Provide engineering leadership and expertise in process development and understanding, process scale-up and manufacturability. + Act as a scientific leader to initiate, drive and deliver science and technology improvement strategies and other improvement activities within and outside the Chemical Development department. + Solve complex scientific problems. + Champion and drive the sustainability of chemical processes with respect to environmental impact, efficiency and cost. + Drive the overall drug substance control strategy, ensuring processes are fully understood and will robustly deliver consistent drug substance quality. + Develop external contacts (industrial and academic) to bring learning and alternative process engineering science into AstraZeneca. + Apply technical knowledge to improvement projects and the evaluation of new technology / processes, ensuring Best Available Technology (BAT) is assessed and implemented. + Mentor and supervise junior colleagues. Essential requirements: + A degree and / or PhD in Chemical Engineering. + Significant experience working in the Pharmaceutical or Fine Chemicals Industry. + Experience in leading technical projects or acting as a lead process engineer on projects. + Experience in chemical engineering solutions for the design and scale-up of novel manufacturing processes, working alongside R&D scientists (chemists, analysts, statisticians and crystallisation scientists) and plant engineers. + A strong understanding of unit operations such as mixing, distillation, liquid-liquid extraction, isolation and drying and their dependency on scale and equipment. + Good collaborative skills to enable effective working with different skillsets. + Have a good understanding of the requirements, principles and application of Safety, Health and Environment (SHE) regulations and Good Manufacturing Practice (GMP). + Strong communication and influencing skills. Preferred Requirements: + Experience of working with CMOs. + Experience in technology transfer and commercial production. + Experience leading and driving improvement projects such as establishing new technology or ways of working. + Experience of working with external partners such as academia on investigating a new technology or processes and implementing these within the company. + Ability to use modelling software (e.g. Aspen, DynoChem, Computational Fluid Dynamics) to support process understanding. Please note that applications must include your current CV and a cover letter and be submitted before midnight on 10th January 2020.