Scientist IV, Mass Spectrometry

Oxford BioMedica Limited ,
Oxford, Oxfordshire
More Details

Overview

Oxford BioMedica is a pioneer of gene and cell therapy and our work is helping to deliver life changing treatments. Gene and cell therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells, providing long term and potentially curative treatments for a wide range of diseases. With the potential to transform medicine, the sector holds significant promise with the first commercial products now launched and others rapidly approaching the market. Our recent successes are driving significant growth. As such, we are looking for a Scientist IV, Mass Spectrometry. The purpose of this role is to conduct Mass Spec based proteome profiling of produce cell line. Specific Work Responsibilities and Deliverables Perform sample preparation for use in mass spectrometry based techniques for the analysis of proteins Daily maintenance, operation and trouble shooting of liquid chromatography-mass spectrometry Generate MS data to characterise cells and complex protein mixtures Analyse MS data using Protein Discovery, Maxquant and Spectronaut Provide basic statistic and bioinformatics analysis of MS data, interpret and present data at internal meetings and external conferences Independently manage daily research activities and support members of staff collaborate with other research departments, perform liquid chromatography-mass spectrometry analysis for collaborative project Draft manuscript and publish research data in peer-reviewed journal Perform tissue culture, siRNA knock down and SILAC labelling experiments Provide technical support across functions at OXB Contribute to research-related activities within Oxford Biomedica Carry on research-related administration (lab management generate SOP & ROP, risk assessment, change control,) Functional Knowledge Required in the Role A bachelor degree or above in area of biology, virology, biochemistry, cell biology or similar A background in biological sciences with a strong interest in learning and applying mass spectrometry in research A background in proteomics, ideally with experience in analysing complex protein mixtures and cells using liquid chromatograph-mass spectrometry It will be desirable to have practical knowledge of metabolomics or virus host interactome Implementation of new innovative techniques and technologies is desirable Excellent knowledge of protein chemistry, cell biology or virology Excellent time management skill and ability to multi-task Proven track record of mass spectrometric usage, trouble shooting and application in research No agencies please

People also viewed