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University of Bristol
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Bristol, Bristol
Research Associate Computational Enzymology
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Job Type: Full-time |
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Salary: £33,797 - £38,017 per annum |
Overview
Research Associate Computational Enzymology Job number ACAD104507 Division/School - School of Biochemistry Contract type - Open Ended Working pattern - Full time Salary £33,797 - £38,017 per annum Closing date for applications 01-Apr-2020 Applications are invited for a full-time postdoctoral researcher in computational chemistry in the School of Biochemistry with Dr Marc van der Kamp. The position is part of a collaborative project on simulation-guided engineering of the product outcome of terpene synthase enzymes, in close collaboration with experimental enzymologists in Cardiff (Prof Allemann, Dr Miller and a full-time postdoctoral researcher) as well as Prof Mulholland (Bristol). You will benefit from collaboration and interactions within the Centre for Computational Chemistry and the Bristol BioDesign Institute (which includes the BrisSynBio research centre), as well as ample computational resources (e.g. through Phase 4 of the BlueCrystal HPC facility in Bristol, one of the largest of its kind in UK universities). The main purpose of the role is to apply existing and new state-of-the-art methods in computational chemistry and enzymology to explore the water binding and reaction pathways in several sesquiterpene synthases. This will involve multiscale molecular simulation to investigate water binding, enzyme mechanism (QM/MM reaction simulations) and dynamics. The aim is to develop combined computational/experimental protocols for engineering the product outcome of these enzymes. You will be expected to analyse and present results, including preparing them for publication, and to liaise with experimental researchers. You will have a PhD (awarded or imminent) in Chemistry or a related subject. The School of Biochemistry is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Bronze Award which recognises its good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. For informal enquiries please contact Dr Marc van der Kamp, email. We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT and BAME communities, to join us.