Physician Geneticist (Director)

GlaxoSmithKline ,
Stevenage, Hertfordshire
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Job Description

Are you a physician-scientist, with experience in genetics and translational research? Do you share a desire to elucidate the genetic basis of diseases, advance biological scientific knowledge and drive the discovery and development of new therapeutics? If so, read more about this unique new role . GSK's ambition is to become the industry leader in genetically validated targets. A dedicated organization, Human Genetics (HG), has been created to achieve this, harnessing recent scientific advancements with a focus on human-derived data and leveraging external partnerships to translate genetic information to high quality targets, ultimately contributing to better medicines with reduced attrition. Click on the link to the video by Erik Ingelsson, SVP Human Genetics, to learn more about the Human Genetics team - In this role, you will work collaboratively with scientists in Human Genetics and multiple Research Units to develop clinical studies that can elucidate biology and contribute to the understanding of drug targets. You will nurture relationships within the industry and academic community, to develop centers who can complete clinical studies to address drug discovery and development questions. The combination of your in-depth experience in genetic and genomic science and your clinical training will lead to the development of ethical and efficient studies in humans. You will also bring breadth and depth of technical and leadership expertise, to successfully support projects through all phases of drug discovery and development. The position is based at our R&D hubs in either Collegeville, PA (US) or Stevenage (UK). We welcome all qualified applicants and would be open to consider alternative flexible/remote arrangements, with a commitment to participate in team's activities and/or travel as needed to perform successfully in the role. This Director level role will provide YOU the opportunity to drive key activities to progress in your career at GSK. These responsibilities include some of the following: * Identify and implement opportunities for genetics-based science to improve GSK target quality and use human genetic evidence to drive decisions on target selection, validation and patient stratification. * Collaborate with internal teams to develop experiments and study proposals that will address key target validation and clinical questions that can be efficiently operationalized in specialized settings in the US and Europe. * Develop and implement studies that will elucidate the role of genetic variants in patients of interest. * Drive the development and execution of collaborations, consortiums and other external relationships focused on the study of the effects of variants in humans. * Be responsible for the design and execution of well-defined genetic studies to provide human genetic information for target validation and medicine development. Be responsible for detailed genetic assessments to inform GSK project progression decisions. * Participate and lead project teams with GSK scientists and external collaborators. * Be responsible for effective communication of genetic findings, with expert interpretation, to relevant stakeholders and project teams. * Find creative solutions and work with agility to address challenging scientific questions. * Contribute to the developing science of drug target identification and validation, providing scientific expertise within Human Genetics and across the Research organization Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: * MD * Broad clinical knowledge and use of clinical research to explore biological questions * Extensive knowledge of (human) genetics and translation into biological function, and ability to apply their experience to drug discovery and development. * A track record of designing clinical studies to elucidate biological knowledge. * Experience in managing complex scientific activities, anticipating challenges in managing patient recruitment, and ability to anticipate and address compliance and governance requirements. * Experience in directing external scientific activities. Preferred Qualifications: In addition to the above, the following characteristics would be an advantage: * MD PhD * Knowledge and experience in the use of observational data for research * Translation of rare disease context to common diseases * Being a subject matter expert in human genetics and applying genetics to drug discovery * Bringing strong leadership skills demonstrating vision and strategy and effective leadership of change. * Superior communication skills to have honest, truth seeking conversations, rather than being progression seeking. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. To bring our values and ex

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