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Barrington James
,
Gloucester, Gloucestershire
Principal Scientist - CNS
Overview
I'm currently working with an innovative early stage drug development company based in Cambridge. Together we are looking for an experienced Scientist with in depth experience in the area of Neurodegenerative diseases specifically Parkinson's Disease, to take the step into a Principal role. This in an incredible opportunity for an individual looking to take on new responsibilities in a company where you are offered the Autonomy bigger companies cant offer. You will lead the translational strategy of the companies main mitochondrial DUB target being developed for Parkinsons Disease as well as drive the ongoing pharmacology studies towards candidate selection and define/execute PK/PD strategy in support of the clinical plan. Responsibilities Identify, validate and develop approaches for prosecuting new drug targets in neurodegenerative diseases. Design and delivery of pharmacology/ pharmacodynamics studies, with strong experience in experimental systems relevant to Parkinson’s Disease. Oversight and management of ongoing and new/planned studies at both academic and contract research organisations. CNS pharmacology leadership for pipeline projects. Effective collaboration management. Critically analyse and interpret data, define realistic timelines for studies and meet delivery deadlines. Execute high impact studies within an extremely fast-paced and collaborative environment. Delivery of pharmacology/pharmacodynamics research reports for inclusion in regulatory documentation. Ensure CNS pharmacology studies are relevant for drug development in human neurodegenerative disease. Support identification and validation of novel therapeutic targets and delivery of new targets into the pipeline. Requirements D. with at least 6 years of relevant pharmaceutical industry experience. Experience working in cross-functional and matrixed Research and Translational teams. Experience in advancement of compounds through project milestones (i.e. candidate selection) as pharmacology line representative. Established scientific reputation in the field of neurodegenerative diseases, in particular Parkinson’s Disease, as evidenced by publication track record. Deep expertise in cell biology and genetics underlying neurodegenerative diseases, in particular Parkinson’s Disease, and extensive knowledge of the drug discovery/development space in this area. Previous experience investigating one or more of the following areas: protein mis-folding and aggregation, protein spreading and seeding, cellular proteostasis mechanisms, neuroinflammation, mitochondrial dysfunction, from a drug discovery perspective, with an emphasis on breakthrough innovation and leveraging human genetic validation. Use of relevant in vitro and in vivo models and experience of working with CROs to deliver in vitro and in vivo Able to establish, maintain and manage effective collaborations with external partners. Previous experience of effective team leading and line management is highly desirable. This opportunity has understandably been incredibly popular. We encourage all interested candidates to apply without delay as it is likely that recruitment will close prematurely. Please direct all questions (if necessary) This job was originally posted as www.totaljobs.com/job/89825269